Vector BioPharma

(Senior) Scientist, Downstream Processing, 100%

Basel, Basel City   |   Full Time

Vector BioPharma AG, a new Basel-based biotech start-up, is recruiting a large team of laboratory technicians and scientists to support the development of gene therapy vectors for a range of applications in pharmaceuticals. We are a technology-driven start-up company providing precision gene delivery solutions that reinvent the way we treat patients. We deploy cutting-edge platform technologies founded in world-class academic research in protein engineering to solve the drug “delivery problem” in a revolutionary new way. We use engineered viral vectors to achieve cell and tissue specific expression of genes and regulators at unprecedented efficacy and safety. We are an international team of scientists, engineers and pharmaceutical professionals committed to excellence in science. We value diversity and inclusion and support our people in their personal and career development. Basel, Switzerland is at the intersection of the Swiss, French, and German borders. The city is well-known for its art, culture, and science, and is regarded as a global hub for the pharmaceutical industry. Our labs are located at Basel’s Technology Park, an established incubator with a proven track record in developing successful biotech start-ups.


In order to support and build up our CMC team we are looking for a Downstream Processing expert. In this role she/he will be responsible for protein and adenovirus purification using state-of-the-art separation techniques. Purification processes are developed in house and in collaboration with contract research organizations (CROs) at R&D scale. Subsequently, the processes developed will be transferred to and implemented at contract manufacturing organizations (CMOs) in order to produce material under GMP to supply Tox and clinical studies. For this challenging position, we are looking for a highly-motivated and experienced Senior Scientist with a proven track record in biologics purification.


RESPONSIBILITIES

  • Development of purification processes required for preparation of adenovirus-based gene delivery vectors and biologics.
  • Close collaboration with and management of CROs supporting external protein and adenovirus purification process development.
  • Transfer of purification processes developed to CMOs for material production under GMP
  • Development of analytical methods required for in-process control of purification processes.
  • Participates in multiple simultaneous projects.
  • Leads the establishment of SOPs for use of specialized equipment, such as chromatography systems, centrifuges, and analytical systems as required.
  • Good communication and support of project leader and team.
  • Presents scientific data internally to team members, e.g., at project team meetings, and possibly to upper management.


QUALIFICATIONS

  • PhD in biology, chemistry, or related field with 5+ years’ of practical experience working in downstream processing, gene/cell therapy, virology or related fields
  • Or M.Sc. with 10+ years’ relevant experience
  • Hands-on experience with protein downstream processing and associated techniques such as chromatography, filtration and centrifugation.
  • Practical experience in methods used for protein and virus analysis to monitor purification efficiency.
  • Knowledge of GMP to develop scalable purification processes applicable under corresponding conditions.
  • Experience with adenovirus preparation and purification or comparable virus systems used for gene delivery would be an asset.
  • Proficiency (e.g., C1 level) in both written and spoken English.


To apply, please send us the application form together with your CV, Cover Letter and 2-3 professional references.

Job-ID:
VBP-014
 
Function:
Scientist
 

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