Vector BioPharma

(Senior) Scientist, Viral Vector Engineering, 100%

Basel, Basel City   |   Full Time

Vector BioPharma AG, a new Basel-based biotech start-up, is recruiting a large team of laboratory technicians and scientists to support the development of gene therapy vectors for a range of applications in pharmaceuticals. We are a technology-driven start-up company providing precision gene delivery solutions that reinvent the way we treat patients. We deploy cutting-edge platform technologies founded in world-class academic research in protein engineering to solve the drug “delivery problem” in a revolutionary new way. We use engineered viral vectors to achieve cell and tissue specific expression of genes and regulators at unprecedented efficacy and safety. We are an international team of scientists, engineers and pharmaceutical professionals committed to excellence in science. We value diversity and inclusion and support our people in their personal and career development. Basel, Switzerland is at the intersection of the Swiss, French, and German borders. The city is well-known for its art, culture, and science, and is regarded as a global hub for the pharmaceutical industry. Our labs are located at Basel’s Technology Park, an established incubator with a proven track record in developing successful biotech start-ups.


The (Senior) Scientist in Viral Vector Engineering is responsible for developing and advancing Vector BioPharma’s gene delivery platform with a focus on engineering novel adenoviral vectors with unique properties for gene therapeutic applications. The engineering of adenoviral vectors will involve advanced gene engineering technologies, sophisticated selection strategies as well as biochemical and cellular characterization of produced vectors. The ideal candidate will have advanced expertise in the modification of large genomes using state-of-the art methodologies, viral vector processing and the characterization of produced vectors in biochemical and cellular assays. Experiences in protein engineering are a plus. He/she must possess excellent verbal and written scientific English communication skills and have up-to-date knowledge of pertinent literature in the field of gene vectors, virology, synthetic biology and biotechnology at large.


RESPONSIBILITIES

  • Performs all duties related to scientific research conducted in the laboratory, including experimental study design, planning, execution, analysis, and reporting.
  • Leads multiple scientific projects with the support of the team leader to fulfill project goals such as the generation and characterization of adenoviral vectors with unique properties.
  • Responsible for problem-solving and the development of innovative and pragmatic solutions to scientific and technical challenges.
  • Leads the generation of new experimental procedures and assays, and the writing of technical reports and SOPs.
  • Conducts training and support of research associates and newly hired scientists.
  • Participates in multiple simultaneous projects.
  • Leads the establishment of SOPs for use of specialized processes, such as the modification of large genomes or the characterization of viral particles as required.
  • Good communication and support of project leader and team.
  • Presents scientific data internally to team members, e.g., at project team meetings, and possibly to upper management.
  • Opportunity to lead a small team of 1-2 research associates as direct reports.


QUALIFICATIONS

  • PhD in molecular biology, virology, biochemistry or related fields with practical experience working in the fields of molecular biology, biochemistry, gene/cell therapy or related fields, or
  • M.S. with 10+ years' relevant experience.
  • 2+ years’ experience in the development of viral vectors preferably in AdV or AAV capsid engineering or genome modification.
  • Practical experience with a diverse set of molecular cloning and assembly techniques, high-throughput screening, gene therapy vectors, cellular assays, molecular biology techniques (ELISA, qPCR, dPCR) or similar laboratory work.
  • Experience in protein engineering is a plus.
  • Proficiency (e.g., C1 level) in both written and spoken English.
  • Must be highly independent, able to work in a fast-growing and highly diverse international team and thrive in a “start-up” environment.
  • Highly precise and organized with good scientific documentation and communication skills.
  • Good computer skills required (MS Office, Apple hardware). Experience with electronic lab notebook (ELN), molecular biology software, data analysis software, or other laboratory software(s) a plus.

New hires will be recruited on a rolling basis starting immediately.


To apply, please send us the application form together with your CV, Cover Letter and 2-3 professional references.

Job-ID:
VBP-018
 
Function:
Scientist
 

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