Vector BioPharma

(Associate / Senior) Director, Immunology of Virus-Host Interactions, 100%

Basel, Basel City   |   Full Time

Vector BioPharma AG, a new Basel-based biotech start-up, is recruiting team leaders to support the development of gene therapy vectors for a range of applications in different pharmaceutical areas. We are a technology-driven start-up company providing precision gene delivery solutions that reinvent the way we treat patients. We deploy cutting-edge platform technologies founded in world-class academic research in protein engineering to solve the drug “delivery problem” in a revolutionary new way. We use engineered viral vectors to achieve cell and tissue specific expression of genes and regulators at unprecedented efficacy and safety. We are an international team of scientists, engineers and pharmaceutical professionals committed to excellence in science. We value diversity and inclusion and support our people in their personal and career development. Basel, Switzerland is at the intersection of the Swiss, French, and German borders. The city is well-known for its art, culture, and science, and is regarded as a global hub for the pharmaceutical industry. Our labs are located at Basel’s Technology Park, an established incubator with a proven track record in developing successful biotech start-ups.


The (Associate / Senior) Director of Immunology of Virus-Host Interactions is a scientist responsible for leading an interdisciplinary team performing R&D in support of Vector BioPharma’s viral vector engineering portfolio. The (Associate / Senior) Director is responsible for planning and conducting scientific research, developing, and leading his/her own team, and analyzing, interpreting, and communicating scientific results under the directives of the senior management. The (Associate / Senior) Director will focus on developing and advancing Vector BioPharma’s gene delivery platform with a focus on the assessment of mitigation strategies to reduce immunogenicity of adenovirus-based viral vectors for a variety of pharmaceutical applications. 


The ideal candidate will have advanced expertise in the assessment of viral-host interactions, adenovirus or other viral biology, gene therapy vectors and the immune responses mounted against them and be familiar with relevant mouse models in order to coordinate preclinical experiments with the preclinical team leader and with external contract research organizations (CROs). Experience in immuno-oncology and/or NHP models is also a plus. The (Associate / Senior) Director must possess excellent verbal and written scientific communication skills in the English language and have experience managing cross-functional collaborations within an organization and with external partners. She/he must have up-to-date knowledge of pertinent literature in the field of immunology, virology, gene therapy and biotechnology at large.


RESPONSIBILITIES

  • Leads a team of at least 2 research associates and scientists as direct reports on-site.
  • Manages and contributes to all duties related to scientific research conducted in the laboratory, including experimental study design, planning, execution, analysis, budgeting, and reporting.
  • Assumes responsibility as internal subject matter expert (SME) for all matters pertaining to the immunology of gene therapy vectors.
  • Participates and actively contributes to success of Vector Biopharma as a member of the leadership team.
  • Organizes and moderates team meetings for direct reports and is responsible for the collection and curation of scientific data for presentation to upper management.
  • Responsible for problem-solving and the development of innovative and pragmatic solutions to scientific and technical challenges encountered by research associates and scientists.
  • Manages the generation of new experimental procedures and assays, and the writing of technical reports and SOPs.
  • Coordinates or conducts hiring, training and support of research associates and scientists.
  • Manages multiple simultaneous projects.
  • Good communication and support internally (i.e., with team and senior management) and externally (i.e., with CROs, partners and collaborators).
  • Fosters an inclusive and supportive environment and promotes career development of direct reports.


QUALIFICATIONS

  • PhD in biology, biochemistry, immunology or related fields or MD with 5 or more years of post-graduate or industry experience working in the fields of gene/cell therapy, immunology, virology, or related fields, or M.Sc. with 15 years or more relevant experience are also welcomed to apply.
  • At least 2 years of experience as a line manager of scientists with two or more direct reports.
  • Extensive experience with immunological and/or viral assay development, gene therapy vectors, mammalian cell culture including human primary cells, flow cytometry (including immunophenotyping), microscopy, molecular biology techniques or similar laboratory work.
  • Proficiency (e.g., C1 level) in both written and spoken English.
  • Must be highly collaborative, able to work in a fast-growing and highly diverse international team and thrive in a “start-up” environment.
  • Excellent scientific communication and presentation skills.
  • Good computer skills required (MS Office, Apple hardware). Experience with electronic lab notebook (ELN) such as Benchling, molecular biology software, data analysis software, or other laboratory software(s) is a plus.


WHAT WE CURRENTLY OFFER

  • Offices: Our well-equipped laboratories and offices are located at the Technologiepark, a premier address for early-stage start-ups in Basel.
  • Commuter Benefits: We support our employees tailored to their personal needs in commuting to work and offer parking facilities or a commuter contribution.
  • Flexible Working: We support flexible working as appropriate.
  • Christmas Closure: In addition to the 24 holidays per year, our offices/labs are closed between Christmas and New Year.
  • Birthday Retreat: On top of that, your birthday is your personal holiday - our employees enjoy their birthday with a day off.
  • Food: We like get-togethers during lunch time. Enjoy tasty, subsidised meals from our FELFEL food fridge.
  • Coffee: Meet up with your colleagues and grab free coffee.
  • Development: We support the individual development of our employees.
  • German Lessons: For our international employees we support German lessons to speed up integration.
  • Creativity: We offer an innovative and creative environment.
  • People: We are an international and diverse team with talented and passionate people.
  • Fun: From time-to-time we organise cool off-site summer and winter team events.

The position is open immediately. 


To apply, please send us the application form together with your CV, Cover Letter and 2-3 professional references.

Job-ID:
VBP-025
 
Function:
Director
 

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